“An IO for you, and an IO for me…”
It is amazing how a series of tweets regarding a topic of interest can inspire a literature hunt leading to a blog post. Case in point:
Medications That Have Been Administered Via the IO Route, As Reported in the Literature
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Medication
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Animal Model
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Clinical Setting
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Adult
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Pediatrics
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Antidotes1
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Atropine
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Y
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Digoxin immune FAB
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Y
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Hydroxocobalamin
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Y
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Methylene blue
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Y
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Pralidoxime
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Y
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Scorpion antivenom
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Y
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Antiseizure Medications2
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Diazepam
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Y
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Fosphenytoin
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Y
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Phenobarbital
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Y
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Phenytoin
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Y
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Y
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Fibrinolytics3
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Alteplase
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Y
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Tenecteplase
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Y
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Paralytic Agents4
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Rocuronium
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Y
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Succinylcholine
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Y
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Y
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Y
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Vecuronium
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Y
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Miscellaneous Agents5
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Adenosine*
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Y
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Y
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Y
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Dexamethasone
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Y
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Etomidate
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Y
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Fentanyl
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Y
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Hypertonic saline
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Y
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Insulin
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Y
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Ketamine
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Y
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Y
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Mannitol
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Y
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Methylprednisolone
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Y
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Midazolam
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Y
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Morphine
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Y
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Propofol
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Y
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Propranolol
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Y
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Radiocontrast dye
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Y
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Recombinant factor VIIa
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Y
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- Antidotes:
- Atropine/pralidoxime: 22738685
- Digoxin immune FAB: 1985666
- Hydroxocobalamin: 22738685
- Methylene blue: 9867898
- Scorpion antivenom: 20728778
- Antiseizure medications:
- Diazepam: 2752998; 9065255
- Fosphenytoin: 12813289
- Phenytoin: 2331255; 2757281; 3778598
- Phenobarbital: 2757281
- Fibrinolytics:
- Alteplase: 20947209; 24054882
- Tenecteplase: 20522435
- Paralytic agents:
- Rocuronium: 16382512
- Succinylcholine: 2216931; 2602189; 8437069; 9885697; 15636659
- Vecuronium: 1352102; 9065255
- Miscellaneous agents:
- Adenosine: 8193689; 8780485; 22217855
- Dexamethasone: 19741408
- Etomidate: 16382512
- Fentanyl: 9065255; 21334506
- Hypertonic saline: 11791047; 15359091
- Insulin: 18326143
- Ketamine: 8362509; 9065255; 18028968; 21334506
- Mannitol: 8437069; 15636659
- Methylprednisolone: 19741408
- Midazolam: 21334506
- Morphine: 8437069; 15636659; 18082778
- Propofol: 9426788; 22720990
- Radiocontrast dye: 21111513; 23726677
- Recombinant factor VIIa: 19317190